Buffalo scored first-quarter touchdowns on a pair of long plays, an 80-yard run by Fred Jackson and a 60-yard touchdown pass from quarterback Ryan Fitzpatrick to wide receiver Naaman Roosevelt. Buffalo added a 49-yard field goal by Ryan Lindell in the closing minute of the first half.
The Giants scored touchdowns on a pair of one-yard runs by Ahmad Bradshaw. The first concluded a nine-play, 69-yard drive. The second a five-play, 89-yard drive that included a 60-yard pass from Eli Manning to Hakeem Nicks. The Giants also got a 26-yard field goal from Lawrence Tynes.
For the Giants, Manning is 13-of-20 for 211 yards. Ryan Fitzpatrick of the Bills is 8-for-10 for 114 yards and a touchdown. Jackson has 107 yards rushing for Buffalo already on just 10 carries.
Buffalo will get the ball to begin the second half.