The numbers seem in the Giants' favor. New York averages 25.3 points per game to place it seventh in the league, while its rushing total of 138.3 yards per week is fifth, its passing yardage of 251.3 per game is seventh and its total yardage clip of 389.6 per game is third.
The Jaguars suffer by comparison, placing in the league's bottom tier in points allowed (27.0, 27th), total defense (376.8, 27th) and pass defense (264.6, 28th). Jacksonville has been just slightly more sturdy against the run by the numbers at least, allowing 112.2 yards per week to place 19th of 32 teams.
Giants quarterback Eli Manning became the seventh passer in league history last week to reach 20 or more touchdown passes in a season for six straight years. Sunday will mark his 100th career game. In his backfield, running back Ahmad Bradshaw is fourth in the league in scrimmage yards with 1,064. Bradshaw, however, will not start this week. After fumbling six times so far this season, Bradshaw is being replaced in the starting lineup by Brandon Jacobs.
On the outside, wide receiver Mario Manningham goes for a third straight home game with a touchdown and tight end Kevin Boss has scored via a pass reception in two of his last three games. Those two players will have to step up as starting wide receivers Hakeem Nicks and Steve Smith are both out with injuries, and backup Ramses Barden is out for the season with a broken ankle. Other targets gaining playing time include Derek Hagan, who caught a touchdown pass last week, as did reserve tight end Travis Beckum.
The Giants are also hurting on the offensive line, where center Shaun O'Hara and left tackle David Diehl are definitely out. Shawn Andrews, replacing Diehl, has been hospitalized with a back injury this week, so that may further deplete the line.
-- Sports Network contributed to this report