Though his receiver arsenal is becoming more anonymous by the day, New York Giants quarterback Eli Manning has remained prolific and looks solid enough against a porous Jacksonville pass defense, regardless of where the ball goes. Mario Manningham has gone from the Giants' third receiver to their No. 1 one guy with injuries to Hakeem Nicks and Steve Smith. Tight end Kevin Boss would also be a solid play. If you are looking for a waiver pickup, Travis Beckum of the Giants might be worth a shot.
As for running backs, sit Ahmad Bradshaw of the Giants. Coach Tom Coughlin has benched him this week in favor of Brandon Jacobs, due to Bradshaw's fumbling issues. Jacobs should see a ton of carries due to the Giants' injuries at wide receiver, so play him.
For the Jaguars, Maurice Jones-Drew is on a roll but faces a daunting task in maintaining the momentum against the Giants. The New York defense is surely a worthwhile play.
-- Sports Network contributed to this report