Defensive end Osi Umenyiora is questionable with a knee injury, and linebacker Keith Bulluck is doubtful with turf toe.
The Umenyiora injury is particularly troubling for the Giants.
The Giants have officially listed him as "questionable" for their game against the Bears on Sunday night.
Umenyiora had this same issue two weeks ago before the Giants game in Indianapolis. At the time, Coughlin described it as a "wear and tear" injury. However, a source familiar with the situation described it as a "new" injury that is likely to bother Umenyiora all season.
It is not the same knee he had surgically repaired in 2008.
If Bulluck can’t play, second-year man Clint Sintim will start.