New York (2-2) fell in Philadelphia, 19-17, on Sunday night after kicker Lawrence Tynes couldn't get enough power behind a 54-yard field goal attempt with only seconds remaining. Quarterback Eli Manning, who threw for 309 yards and two touchdowns, also threw a crucial red zone interception in the second half to Eagles cornerback Dominique Rodgers-Cromartie.
The Browns (0-4), meanwhile, haven't played since last Thursday, when their second half rally against the Baltimore Ravens fell short as they were edged, 23-16. Rookie quarterback Brandon Weeden threw for 320 yards in the loss, but also threw a critical interception that was returned for a touchdown by Ravens corner Cary Williams.
Currently, the Giants are listed as 10-point favorites according to OddsShark, and the over/under is resting at 44.
Kickoff is scheduled for 1 p.m. ET at MetLife Stadium, and the game will be televised on CBS.