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Week 6 NFL odds, Giants vs. 49ers: San Francisco favored in opening line

The San Francisco 49ers are favored in the opening lines for this Sunday's game against the New York Giants.

Nick Laham - Getty Images

The San Francisco 49ers are favored for Sunday's rematch of the 2012 NFC Championship game against the New York Giants. The opening line has San Francisco by 3 points with a total set at under 45, according to SB Nation odds powered by OddsShark has the 49ers favored by 7 points with the total set at over 45.5.

New York will be entering the game on the back of a dominating 41-27 victory over the Cleveland Browns. After falling into an early 14-0 hole, the Giants managed to score 20 points in the second quarter to take a 27-17 lead into halftime. Quarterback Eli Manning completed 25-of-37 pass attempts for 259 yards, three touchdowns (all of which went to receiver Victor Cruz) and one interception. Running back Ahmad Bradshaw ended the day with 200 yards rushing and one touchdown on 30 attempts.

San Francisco will bring a two game winning streak into the contest. The team has dominated its opponents over that span, outscoring them by a collective margin of 79-3. With the exception of their Week 3 loss to the Minnesota Vikings, the 49ers have managed to score at least 27 points in every other game this season.

The game is scheduled to take place this Sunday at Candlestick at 4:25 p.m., ET and will be broadcast on Fox.