The last time the New York Giants and San Francisco 49ers faced off, a trip to the Super Bowl was on the line. The stakes are lower now, but both teams still want to grab that always-important 'W' on Sunday.
Eli Manning and the Giants (3-2) travel to the West Coast to take on the 49ers (4-1) and quarterback Alex Smith, who said earlier this week his team has "unfinished business" with the Giants.
Kickoff is scheduled for 4:25 p.m. ET on FOX.
The Jets (2-3) will also be in action Sunday. They'll host the Colts (2-3), who are coming off a 30-27 win over Green Bay last weekend. The Jets lost to the Texans, 23-17, on Monday. The game is set for 1 p.m. ET on CBS.
Here is the full NFL schedule for Week 6 (all times ET):
Thursday, Oct. 11
Sunday, Oct. 14
Colts at Jets, 1 p.m., CBS
Giants at 49ers, 4:25 p.m., FOX
Packers at Texans, 8:20 p.m., NBC
Monday, Oct. 15