Philadelphia used a strong third quarter to expand its lead heading into the final frame, and the Nets couldn't get enough going in the fourth to creep back into it.
Kris Humphries did his part for New Jersey, finishing with a team-high 20 points and 10 rebounds, his fourth double-double in his past five outings.
But Philadelphia's bench proved too much for the Nets, as the trio of Lou Williams, Thaddeus Young and Spencer Hawes teamed up for 58 points from their reserve roles.
With the loss, New Jersey drops to 9-20 at home this season and 21-38 overall. The Nets will next take the court on Friday when they rematch with the 76ers in Philadelphia.