New Jersey, who trailed by one entering the second period, saw its deficit increase to three after goals from Stephen Weiss and Marcel Goc.
Weiss scored his second goal of the game just 1:12 into the middle frame. With the Devils still killing off a 5-on-3 powerplay, Goc was hit with a shot in front of Martin Brodeur. The loose puck bounced to the stick of Weiss, who had the entire net to shoot at for his second goal of the postseason.
Weiss became the first player in the series to record a multi-goal game.
Goc scored his first goal of the postseason at the 14:39 mark, extending the Panthers lead to 3-0. Goc fired a shot from the right circle that hit the shoulder of Brodeur and rolled behind the Devils goalie.
The Panthers are 3-for-6 on the powerplay in the series. During the regular season, Florida scored almost a quarter of their goals on the power play, and it was one area the New Jersey acknowledged it would need to control to win the series.
Jose Theodore, who allowed three goals in Friday night's loss, has stopped all 13 Devils shots.