Eli Manning and company were upset in Week 1 by the Dallas Cowboys last Wednesday on national television. Now, Tom Coughlin's squad will face a tough Tampa Bay team led by ex-Rutgers coach Greg Schiano.
The defense will be looking to improve after their 2012 debut, which saw them allow 433 total yards - including 129 to DeMarco Murray on the ground.
On the injury front, Hakeem Nicks and Prince Amukamara are both questionable. The star wideout is still dealing with a nagging foot problem while Amakamara has a balky ankle.
The Bucs come to the Big Apple following a home win against the Carolina Panthers. They'll most likely be without cornerback Anthony Gaitor (hamstring), who's listed as doubtful. Tackle Jeremy Trueblood is questionable with an ankle issue.
Game Time: 1 p.m. ET