The New York Giants and St. Louis Rams each enter their Monday Night Football matchup (8:30 p.m. ET, ESPN) 0-21, and as two of the more injury-riddled teams in the NFL. The Giants have a Week 3 showdown looming with NFC East rival Philadelphia, so this is a must-win for a team that came into the 2011 NFL season determined to end a two-year playoff drought. The Giants are currently 7-point favorites in their home opener at MetLife Stadium
The game pits Giants coach Tom Coughlin against St. Louis coach Steve Spagnuolo, the Giants defensive coordinator in 2007 and 2008. This is the first time the two have coached against each other.
Keys to the game will include whether or not the Giants can establish and stay with the run, and whether or not they can eliminate the mistakes in the defensive secondary that plagued them in the season-opening loss to Washington.