Pettitte, 39, made four starts in the minor leagues during his warmup for a return to MLB action after a year-long retirement. Pettitte was 0-2 in those minor league games and had a 3.71 ERA.
Pettitte's last start in the majors was Oct. 18, 2010 against Texas in the ALCS. He finished that All-Star season with a record of 11-3 and an ERA of 3.28.
Overall, Pettitte has a record of 240-138 with an ERA of 3.88. He has struck out 2,251 batters during his MLB career which has been solely with the Yankees save for three years with the Astros (2004-2006). Pettitte is also 19-10 as a postseason starter with an ERA of 3.83.
Cashman did not say which pitcher would be removed from the Yankees rotation. It seems likely, however, that rookie David Phelps would return to the bullpen. Phelps makes his second big-league start Wednesday night against the Tampa Bay Rays.
See Pinstripe Alley for more discussion and analysis of the Yankees.