In addition to Santonio Holmes, the Jets will also be without tight end Dustin Keller, wide receiver Stephen Hill and fullback John Conner. Keller will miss his fourth straight game with a hamstring injury he suffered in the season opener. Hill, also out with an injured hamstring, will miss his second straight game.
On the defensive side of the ball, the Jets will be forced to play without nose tackle Sione Pouha. Pouha, who has been dealing with a back injury since training camp, will miss his second game of the season.
While the Jets will be missing a number of offensive weapons, Houston will also be without one of their key players. Backup running back Ben Tate is inactive with a toe injury. That will mean the Jets will likely see a heavier dose of Arian Foster. While Tate is out, Andre Johnson and Owen Daniels are both active.
Here is the complete list of inactives for both teams: