Holmes hurt his left foot in the fourth quarter of the team's 34-0 blowout loss to the San Francisco 49ers. His injury cost the team a touchdown as he dropped the ball in pain, allowing San Francisco to scoop the ball up and score a 51-yard fumble return, but the potential consequences could be much bigger. Holmes left the field on a cart and was seen with crutches and his foot in a boot after the game. Rex Ryan would not comment on the injury, although it was made known that the Jets' No. 1 wideout would be having the MRI to determine the injury's severity.
The Jets also suffered two additional injuries on contributors to the team's offense. John Conner left the game with a hamstring injury and did not return, leaving the team without a fullback on the roster. That put the Jets in the unique position of using Tim Tebow as a blocker for Mark Sanchez on several passing downs. Conner had missed Week 3's game against the Dolphins and was replaced by tight end Konrad Reuland. One of Reuland's backups, tight end Dedrick Epps, also left the game after hurting his knee. Epps, who the Jets signed Sept. 14 and had missed earlier games with injury, caught his first career reception on Tebow's first passing attempt with the Jets. But like Holmes, Epps was injured while carrying the ball and fumbled.