The last time the New York Giants and San Francisco 49ers faced off, a trip to the Super Bowl was on the line. The stakes are lower now, but both teams still want to grab that always-important 'W' on Sunday.

Eli Manning and the Giants (3-2) travel to the West Coast to take on the 49ers (4-1) and quarterback Alex Smith, who said earlier this week his team has "unfinished business" with the Giants.

Kickoff is scheduled for 4:25 p.m. ET on FOX.

The Jets (2-3) will also be in action Sunday. They'll host the Colts (2-3), who are coming off a 30-27 win over Green Bay last weekend. The Jets lost to the Texans, 23-17, on Monday. The game is set for 1 p.m. ET on CBS.

Here is the full NFL schedule for Week 6 (all times ET):

Thursday, Oct. 11

Steelers at Titans, 8:20 p.m., NFL Network

Sunday, Oct. 14

Raiders at Falcons, 1 p.m., CBS

Rams at Dolphins, 1 p.m., FOX

Cowboys at Ravens, 1 p.m., FOX

Chiefs at Buccaneers, 1 p.m., CBS

Colts at Jets, 1 p.m., CBS

Bengals at Browns, 1 p.m., CBS

Lions at Eagles, 1 p.m., FOX

Bills at Cardinals, 4:05 p.m., CBS

Patriots at Seahawks , 4:05 p.m., CBS

Giants at 49ers, 4:25 p.m., FOX

Vikings at Redskins, 4:25 p.m., FOX

Packers at Texans, 8:20 p.m., NBC

Monday, Oct. 15

Broncos at Chargers, 8:30 p.m., ESPN