Humphries sprained his ankle near the end of Wednesday's 110-93 loss to the Oklahoma City Thunder. Humphries, a 6-9 forward in his ninth NBA season out of Minnesota, has averaged 7.2 points and 7.3 rebounds this season in 27 games.
Watson will sit out his second game in a row with a bruised right knee, also missing Wednesday's loss to the Thunder. The six-year veteran is in his first season with the Nets, and he's averaging 18.2 minutes per game behind Nets point guard Deron Williams. Watson is averaging 6.3 points and 1.7 assists for Brooklyn so far this season, and he appeared in each Nets game of the year until Wednesday.
The Nets have won three of four games since coach Avery Johnson was fired and P.J. Carlesimo took over as the interim head coach. The Nets play at Washington on Friday night before hosting the Sacramento Kings on Saturday.