The Yankees' Phil Hughes will oppose Felix Doubront.
Hughes, making his 29th start of the season, has been consistently inconsistent throughout 2012. At 14-12, Hughes has not won or lost more than three consecutive starts, but has posted a decision in his last 10 starts dating back to July.
The Yankees defeated the Red Sox on Wednesday thanks to two home runs by Curtis Granderson.
The Red Sox may be without second baseman Dustin Pedroia, who left midway though Wednesday's game to be with his wife, who went into labor with the family's second child.
First pitch is scheduled for 7:10 p.m. ET.
TV: YES, MLB Network
Radio: WCBS 880, WADO 1280