With 14:53 remaining in the third quarter, Jets running back Joe McKnight ran up the middle for one yard. When the pile cleared, Mangold remained on the ground, face first.
Replay showed that when the tackle pile moved toward Mangold, Texans defensive end J.J. Watt rolled up on Mangold's right ankle. He remained on the ground for a few minutes before walking off the field gingerly with the help of two trainers. Mangold was replaced by Matt Slauson at the center position.
ESPN has reported Mangold's return to be questionable.
The Jets run game struggled mightily Monday night prior to the injury to their All-Pro center. New York has only 43 rushing yards.
Mangold is in his seventh NFL season, all with the New York Jets. He has made the Pro Bowl four times.