Eli Manning -- He is on pace for more than 5,000 yards passing. Even facing the vaunted San Francisco 49ers defense there is no reason not to play him.
Victor Cruz -- With Hakeem Nicks down Cruz is getting all manner of extra attention from defense, and that will continue Sunday. Consequently, his yards per catch are down. He still caught five passes last week and scored three touchdowns.
Domenik Hixon -- If you need a second receiver he's a good option. Just like he has been for the Giants.
Martellus Bennett -- The big tight end has risen in stature, both with the Giants and Fantasy team owners. He hyper-extended his knee Sunday against the Cleveland Browns, though. If he plays against San Francisco it doesn't seem likely he would be much of a vertical threat.
Hakeem Nicks -- There is some talk that the star wide receiver might play. He has missed three straight games with foot and knee issues, though, so don't count on it.
Ahmad Bradshaw -- How can i put him here after a 30-carry, 200-yard performance? Well, the Giants are playing the 49ers. New York's running offense is improved from a season ago but I am just not buying in totally and believing they can have the kind of success against San Francisco that would make Bradshaw a smart play.